Pain relief. Inflammatory relief. Anxiety relief. Digestive relief. Insomnia relief. Stress relief.
That’s the word out there on the wonders of CBD, but none of it is substantiated beyond the rare study and spontaneous but broad anecdotal evidence. Just like other supplements, the effects must meet the satisfaction of the federal agencies that oversee these substances and claims. As of this writing, the federal government does not accept them as valid. (....For the protection of the consumer, of course, but note: the state/federal legality is still a quandry.) Many studies are underway at this writing for scientific and legal review. Let’s gather some concrete information, then we can talk about our experiences.
Excerpt from the Hindawi Journal of Toxicology Volume 2018, Article ID 8143582:
“Cannabis sativa is a unique and complex plant with respect to its constituents and physiological properties…. Despite the fact that humans have utilized the C.sativa plant medicinally for millenia, its chemical profile and complex pharmacology have yet to be fully elucidated.”
“Cannabinoids are chiefly known to act on the cannabinoid receptors CB1 and CB2. ….CB1 receptors are primarily found in the central nervous system but are also found in peripheral tissues, including those of the pituitary gland, gastrointestinal system, reproductive system and immune system. CB2 receptors are found in the central nervous system (neuronal microglia cells, brain stem cells, and cerebellum) as well as peripherally in tissues such as the spleen, thymus, tonsils, mast cells, and reproductive system.”
From the U.S Hemp Roundtable general literature:
“Cannabinoids are compounds that are native to plants and humans. Hemp contains phytocannabinoids (phyto = plant), one of which is cannabidiol, or CBD. Our bodies also make cannabinoids called endocannabinoids (endo = within) that support proper function of several key operations, including the digestive system, central nervous system and even your immune system.
CBD is the most commonly known phytocannabinoid in hemp, but there are other substances known as terpenes and flavonoids that contribute to hemp’s chemical profile. In addition, hemp offers protein, essential amino acids, ALA Omega-3, fiber and a range of vitamins and minerals.”
NYT Magazine excerpt from The ABDs of CBD by MoisesVelasquez-Manoff May 19, 2019:
“...how CBD works is less clear. It seems to interact with multiple systems: increasing the quantity of native cannabinoids in the human body; binding with serotonin receptors, part of the “feel good” molecular machinery targeted by conventional S.S.R.I.s; and stimulating the GABA receptors, responsible for calming the nervous system. With more than 65 cellular targets, CBD may provide a kind of full-body massage at the molecular level.
This biochemical promiscuity is one reason CBD seems so promising, according to Yasmin Hurd, a neuroscientist at Mount Sinai, in New York. Modern neuroscience often tries to target one pathway or receptor, Hurd told me; that approach is easier to study scientifically, but it may not address what are often network-wide problems. “The brain is about a symphony’” she says. And CBD she suspects, can “bring the entire symphony into harmony”.”
Former NFL Running Back Ricky Williams
quoted in Massage & Bodywork magazine Sept/Oct 2019:
“I remember my first massage using a CBD salve. After the massage, I felt my whole body was awake and alive and vibrating. I realized this could be really powerful for people therapeutically. It was a profound experience for me.”
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So ultimately, we have to guess about dose, efficacy, use and where each of us might be in the strength or vitality of our unique native endocannabinoid systems. This system produces endocannabinoids and enzymes to support and regulate optimal function in the body’s various systems and is responsible for maintaining homeostasis. Stress or trauma sets the wheels in motion and the endocannabinoid system is a first responder. Beyond the endocannabinoids we make for this system, when we introduce hemp or marijuana, the CBD or phytocannabinoids in those substances will go to those sites, hence the effect on our systems.
There is the question of absorption in topical application. When determining how a substance makes its way through the many layers of skin, there are several factors - higher fat solubility matters, as does molecular weight, and whether or not the formula is full spectrum and contains raw or gently heated CBD. Raw formulas do not penetrate the blood-brain barrier. Our full spectrum CV Services plusCBD is approximately 49% essential fatty acids, for example, and the gold formula is gently heated, so this facilitates penetration to the bloodstream despite a high molecular weight. The truth is, there are many CB receptors in the skin, so that the phytocannabinoids effectively signal through the pathways - stepping stone neurotransmitters - and whether the blood stream shows evidence of absorption is a reasonable study for the future.
CAUTION: For those on pharmaceutical medications, please be aware that CBD can inhibit or neutralize the function of some liver enzymes, and since all pharmaceuticals are broken down in the liver, you want to check with your physician or pharmacist to see what contraindications might exist.
What our clients have reported:
“This works beautifully for my old dog who has hip dysplasia.”
“I started the drops expecting to have better sleep. I slept through the night and was then delighted to find it changed my IBS for the better.”
“The gummies are my “go to” for anxiety. Easy to dose and keep track of.”
“ My knees aren’t screaming after walking six blocks.”
CV SERVICES is the main brand we carry for ingestibles, and their literature regarding CBD from their hemp grown in the Netherlands states:
“A growing body of scientific evidence and controlled studies is supporting its health-related properties, including:
Antioxidant properties on par with or greater than Vitamins A, C, and E
Calming qualities similar to melatonin and magnesium and ability to support mood, sleep, and brain health
Ability to help promote metabolic wellness similar to cinnamon extract or chromium
Healthy inflammation response support
Broad-spectrum nutrition; rich not only in phytocannabinoids, but also fatty acids, terpenes, plant-derived sterols, chlorophyll and naturally-occurring Vitamin E”